Oral rehabilitation

Oral rehabilitation relates to the diagnostic process, treatment planning, and rehabilitation of oral
function, and to its maintenance. This field encompasses elements from most of the disciplines normally
associated with dental treatment: filling and crowning teeth damaged by dental caries, erosions (acid
damage), wear and abrasion (caused by tooth-grinding, for instance), and trauma (blows). The damage
can be so extensive that root-canal treatment becomes necessary.

The field also covers the replacement of teeth that have been lost as a result of caries, periodontal disease, or trauma, or which are lacking due to hereditary conditions. Tooth replacements are made using biocompatible materials, and they can be fastened on existing teeth (bridges) or implants, or be supported by existing teeth, implants, and the oral mucous membrane (dentures). We conduct research to optimize the methods and techniques used for these dental treatments. Our research is many-faceted, and in our work we test various hypotheses using methods such as mechanical testing in a laboratory environment, computer simulation, and animal models. In addition, much of our activity takes place as clinical studies where in some areas we have been following our patients for 20 years.

When correcting poor dentition and abnormal or defective mandibular growth, we use orthodontics and, in more challenging cases, a combination of orthodontic appliances and jaw surgery. One element of oral rehabilitation therefore involves clinical and experimental animal testing as we seek to develop and improve the treatment options for correcting congenital or acquired deformities of the maxillofacial skeleton. As part of these efforts, bone growth, modelling and remodelling are assessed in relation to mechanical forces exerted upon the bone (which can be around teeth, for example, or oral mini-implants). Tests are done partly on humans, partly as animal experiments, and partly on cell cultures. Through these investigations we can learn how to optimally exert force on teeth and bone tissue when providing orthodontic treatment.

Weighing the risks gives the best outcome
Whether we are working to rehabilitate the teeth of a senior citizen or an adolescent, the crucial question is: Which treatment methods will yield the best results, with the fewest complications in the long term? In some cases we strive to maintain the tooth in the patient’s mouth. In other cases, treatment may aim to improve the patient’s ability to chew, smile, or speak – the issue being improved quality of life. Consequently, when testing principles we also seek to determine how dentists can give their patients the best possible treatment, even while considering the potential risks that dental treatment can entail.


  1. Clinical, radiological, and histological evaluation of bone reactions at immediately loaded free-standing implants in monkeys. Immediately loaded implants are compared both with implants that have healed prior to occlusal loading and with non-loaded implants.
  2. Long-term observations of tooth replacements (single-tooth implants, bridges, or adhesive bridges). Survival and complications are assessed for several groups of patients, including persons with tooth loss due to aggressive marginal periodontal disease; some patients have been followed for 20 years.
  3. Research concerning patients with disturb- ances in dentofacial growth and mandibular function caused by pathological conditions in the temporomandibular joints, including patients diagnosed with juvenile idiopathic arthritis; for instance the evaluation of bone distraction in patients with juvenile idiopathic arthritis.
  4. Studies of bone reaction to various biomechanical loads; for instance specific bone tissue reactions under certain physiological and pathological conditions in an animal model, using orthodontic biomechanical loading.


Excessive masticatory force can cause osseointegrated oral implants to lose osseointegration
(Isidor F. Clin Oral Impl Res. 1997;8:1–9)

The greatest reduction in alveolar bone volume after tooth extraction takes place within the first year
(Schropp L. Int J Periodont Rest Dent. 2003;23:313–23)

3D analysis and evaluation of orthopaedic treatment of abnormal mandibular growth pattern
(Cattaneo PM. Comput Meth Biomech Biomed Engin. 2005;8:157–65)

Investigations relating to biomechanics, bone biology, and orthodontic treatment of adult patients
(Melsen B. Editor. Adult Orthodontics. Wiley- Blackwell, Chichester, West Sussex, UK. ISBN: 978-1-4051-3619-8)


Clinical evaluation and animal experiments (with subsequent histological evaluation), mechanical testing and similar tests in the laboratory, and also computer simulation.

  • Clinical assessment of treatment outcomes: function, aesthetics, patient satisfaction, complications, survival of tooth/implant, and restoration
  • Radiological evaluation of treatment outcomes
  • Hard-tissue histology of bone reactions to mechanical loads
  • Tensile and fracture strength of test specimens subject to static and dynamic load
  • Computer simulation of the effect that load on teeth and implants has on the surrounding tissues, and particularly on bone.


Flemming Isidor

Phone: +4587168127

Golnoush Bahrami Møller
Associate professor

Phone: +4587168148

Dorthe Arenholt Bindslev
Professor with Special Responsibilities


Thomas Klit Pedersen
Professor with Special Responsibilities

Phone: +4587168079