Forskning på Ortodonti

General Research


The general research profile of the Department of Orthodontics can be summarized under the headings:

  • Tissue Reaction to Bio-Mechanical Stimulus Under Normal and Pathological Conditions
  • Mechanics of Orthodontic Wires
  • Healing of Bone Defects Under Various Conditions
  • Study of the Pathogenesis of the Condylar Reaction to Juvenile Rheumatoid Arthritis and the Effect of Treatment Aiming at the Distraction of the Condyle

Tissue Reaction to Bio-Mechanical Stimulus Under Normal and Pathological Conditions
This research field covers the biological aspects of the application of known force systems both in-vivo and in-vitro. The in-vivo models include human clinical studies and animal experiments, in which implants and teeth are loaded in monkeys and rats. Furthermore, a rat model is developed for the study of tissue reaction to loading under pathological conditions with known metabolic diseases.
On tissue level, in-vitro studies are performed with the use of a special appliance for the generation of uniform strain on cultures of periodontal ligament cells as well as osteoblast-like cells. In addition, finite element analyses are used to simulate the experiments to assess stress and strains in the various tissues. The ultimate aim is to be able to make computer simulations of the entire process of orthodontic tooth movement.

Mechanics of Orthodontic Wires
Under this profile both the development of well defined force systems and their biological reaction are studied. A biomechanical laboratory, equipped with a force identification system and a material testing machine, is available. The delivery of force systems from both existing and new designs of orthodontic appliances are mechanically assessed, and, in case of the latter, pre-clinically tested. The effect of friction between wire and bracket can also be evaluated.

Healing of bone defects under various conditions
In relation to this problem a standardized rat model comprising critical size defect of the calvaria is used. Various types of guided tissue regeneration have been studied and lately the influence of different types of growth hormones and growth factors on healing has been tested.

Study of the Pathogenesis of the Condylar Reaction to Juvenile Rheumatoid Arthritis and the Effect of Treatment Aiming at the Distraction of the Condyle
Based on the centralisation of the treatment of children suffering from Juvenile Arthritis, it was possible to develop a classification system in relation to which a prediction of the risk and severity could be performed. The treatment regimen is closely related to the state of the general disease and it has been shown that the well known affection of the growth of the craniofacial skeleton can be limited. The tissue reaction to the clinical therapy will be studied in a rabbit model, in which TMJ Arthritis has been experimentally generated.



Recent PhD Theses

Kofod, T : Intraoral unilateral mandibular distraction osteogenesis for correction of unilateral mandibular

hypoplasia  and asymmetry, 2005.

Küseler, A.: Aspects of involvement of the temporomandibular joint in children with juvenile idiopathic arthritis, 2004.

Cattaneo, PM.: Orthodontic aspects of bone mechanics and bone remodelling, 2003.

Verna, C.: The influence of different bone turnover rates on the tissue reactions to orthodontic load, 1999.

Klit Pedersen, T.: Children with Juvenile Chronic Arthritis; Risk of Condylar Destruction; Effect of Early Treatment, 1996.

Boldrup Nielsen, L.: Mechanical Stimulation of Osteogenic Cells in Culture, 1996.

Bosch, C.: Bone Regeneration in Calvarial Defects, 1996.



Recent MSc Theses

Serra, E. Influence of local anesthetic on the corticomotor response to tongue training, 2009.

Annousaki, O. The influence of two self-ligating systems on the incisor position, 2009.

Jørgensen, T.P. Mandibular condylar dimensions, 2008.

Aulack, R.S. The effect of in vitro mechanical loading on Cbfa1 gene expression in osteoblasts, 2007.

Botticelli, S. A comparison between 2D conventional and 3D volumetric imaging in case of unerupted maxillary canines, 2007.

Lemor, C. Bone and periodontal ligament studied on autopsy material from adult humans. A histomorphometric analysis, 2007.

Laursen, M.L. A three dimensional description of the human tooth alveolar bone complex, 2007.

Jonsdottir, S. Metabolic activity of human osteoblasts after mechanical loading in vitro, 2006.

Kjellerup, T. Patient satisfaction and occlusal outcome in orthodontically treated adults, 2006.

Mosby Nielsen D. Early versus late treatment of posterior crossbite in relation to TMD (Temporo Mandibular
Disorders) and asymmetry of the face in 16-17 year olds in Århus Kommune, 2006.

Thormann, J. A new method for 3-D tooth movement analysis, 2006.

Guilbert, G. Evaluation of three bracket positioning machines: LinguSet ® , Ray-Set ® and Bracketron ® , 2005.

Halkjaer Jensen, L. Cortical control of human tongue muscles. Effects of peripheral sensory nerve pertubation and deprivation, 2005.

Kirk Christensen, MF. Bidkraft, smerteopfattelse, hovedholdning samt symptomer og fund på temporomandibulære funktionsforstyrrelser hos voksne ortodontiske patienter, 2005.

Luzi, C. The AarhusAnchorage System ®. Histological and clinical evaluation, 2005.

Chatzikallinikidis, C. Clinical observation of asymmetric cases treated with two different modalities: Segmented vs Straight-wire, 2004.

Wermuth, S. Cellulære reaktioner på mekanisk påvirkning, 2004.

Hanquist Hansen, J. Do the material properties of superelastic wires change after heat treatment?, 2004.

Arenholt-Bindslev, D. Material related adverse reactions in orthodontic patients - with special emphasis on aspects of nickel hypersensitivity, 2004.

Garbo, D. Evaluation of masseter muscle volume and structure by magnetic resonance imaging in distraction osteogenesis of the human mandible, 2003.

Troiani, S. Influence of lower incisors proclination on the development of gingival recessions: a follow-up study, 2003.

Gudde, M. Development of recessions on the buccal gingiva of combined orthodontic-surgical patients, 2003.

Torkashvand, H. Microstructure analysis of the alveolar bone proper using histology and micro-computed tomography, 2002.

Verna, C. Root resorption curing orthodontic tooth movement under different metabolic conditions in rats, 2002.

Aarslev, I. Maksimal Bidkraft hos Danske Børn, 2002.

Dahl, R. Combi-pull headgear as anchorage in extraction cases - A 3-dimensional analysis of molar movement, 2002.

Rizzo, L. Comparison between a modified light-curing denture base resin and conventional composite resins for bonding of orthodontic bracket - An in vitro and in vivo study, 2001.

Veiga, M. Chemical composition and biointegration of 45S5 Bioglass â particulate bone grafting material in a rat calvarial defect model, 2001.

Würtz, V. Force systems generated by long, curved cantilevers in different configurations, activated for intrusion, 2001

Hartig, LE. The influence of steroid treatment on orthodontically induced root resorption, 2001

Birn, LB. Orthodontic treatment of asymmetries. An evaluation of treatment outcome in a group of asymmetric patients, 2001

Donker, H. Bacterial degradation of composite bonding materials, 2000

Pettas, A. Combi-pull headgear as anchorage in Class II extraction cases, 2000

Bassarelli, T. Palatal expansion and gingival recession in adults, 2000

Kvamm, A. ”Changes in hard tissue, soft tissue and function caused by distraction osteogenesis, 2000

Manoukakis, J. Position and eruption pattern of the tooth germs in the early mixed dentition as determinants of dental crowding, 1999

Cacciafesta, V. Bone regeneration in rat calvarial defects - The influence of growth hormone treatment, 1999

Kalia, S. The Influence of Steroid Treatment on Orthodontically Induced Tissue Reaction, 1998

Nidoli, M. Difference in Osteoinductive Capacity between Endochondral and Intramembranous Demineralized Bone Matrices in Rats, 1997

Jones L. Mechanical Strength of Healed Calvarial Defects in Rats Implanted with Different Osteopromotive Substances. University of Aarhus, 1997

Kakkou, M. Tooth Mobility Pattern during Orthodontic Tooth Movement Assessed by the Periotest, 1996

Terzoudi, T. Long-Term Assessment of Psychological Outcome of Orthognathic Surgery, 1996

Menghi, C. 3-D Experimental Identification of Force Systems from Orthodontic Loops under Different Modes of Activation, 1995



Selection of Recent  Articles


Stoustrup, P., Kristensen, K.D., Küseler, A., Pedersen, T.K., Gelineck, J., Herlin, T.Intra-articular vs. systemic administration of etanercept in antigen-induced arthritis in the temporomandibular joint. Part II: mandibular growth. Pediatric Rheumatology 2009, February.

Kristensen, K.D., Stoustrup, P., Küseler, A., Pedersen, T.K., Nyengaard, J.R., Hauge, E., Herlin, T. Intra-articular vs. systemic administration of etanercept in antigen-induced arthritis in the temporomandibular joint. Part I: histological effects. Pediatric Rheumatology 2009, February.

De Zee, M., Cattaneo, P.M., Svensson, P., Pedersen, T.K., Melsen, B., Rasmussen, J., Dalstra, M. Prediction of the articular eminence shape in a patient with unilateral hypoplasia of the right mandibular ramus before and after distraction osteogenesis - a simulation study 2009, February.

Dalstra, M., Melsen, B. From alginate impressions to digital virtual models: accuracy and reproducibility. Journal of Orthodontics 2009;36:36-41.

Cattaneo P.M., Dalstra, M., Melsen, B. Strains in periodontal ligament and alveolar bone associated with orthodontic tooth movement analyzed by finite element. Orthodontic Craniofacial Research 2009;12:120-128.

Laursen, M.G., Melsen, B. Multipurpose use of a single mini-implant for anchorage in an adult patient. Journal of Clinical Orthodontics 2009;43:193-199. Case report.

Luzi, C., Verna, C., Melsen, B. Immediate loading of orthodontic mini-implants: a histomorphometric evaluation of tissue reaction. European Journal of Orthodontics 2009;31:21-29.

Luzi, C., Verna, C., Melsen, B. Guidelines for success in placement of orthodontic mini-implants. Journal of Clinical Orthodontics 2009;43:39-44.

Cattaneo, PM.,  Dalstra, M., Melsen, B. Moment-to-force ratio, center of rotation, and force level: a finite element study predicting their interdependency for simulated orthodontic loading regimens. Am J Orthod Dentofacial Orthop. 2008;133:681-689.

Cattaneo, PM., Melsen, B. The use of cone-beam computed tomography in an orthodontic department in between research and daily clinic. World Journal of Orthodontics. 2008;9:269-282.

Korn, M., Melsen, B. Early treatment with a maxillary lip bumper-bite plateau combination. Angle Orthod 2008;78:838-846.

Jones, L., Thomsen, JS., Mosekilde, L., Bosch, C., Melsen, B.Biomechanical evaluation of rat skull defects, 1, 3 and 6 months efter implantation with osteopromotive substances. J Craniomaxillofac Surg. 2007;35:350-357.

Ciarlantini, R., Melsen, B. Maxillary tooth transposition: correct or accept? Am J Dentofacial Orthop. 2007;132:385-394.

Luzi, C., Verna, C., Melsen, B. A prospective clinical investigation of the failure rate of immediately loaded mini-implants used for orthodontic anchorage. 2007;8:192-201.

Cattaneo, PM., Dalstra, M., Melsen, B. Analysis of stress and strain around orthodontically loaded implants: an animal study. Int. Oral Maxillofac Implants. 2007;22:213-225.

DeZee, M., Dalstra, M., Cattaneo, PM., Rasmussen, J., Svensson, P., Melsen, B. Validation of a musculo-skeletal model of the mandible and its application to mandibular distraction osteogenesis. J Biomech. 2007;40:1192-1201.

Dalstra, M, Cattaneo, PM, Beckmann, F. Synchrotron radiation-based microtomography of alveolar support tissues Orthodontics & craniofacial research. 2006;9:199-205.

Verna, C., Hartig, L., Kalia, S., Melsen, B. Influence of steriod drugs on orthodontically induced root resorption. Orthod Craniofacial Res. 2006;9:57-62.

Melsen, B., Melsen, C. Die Zukunft in der virtuellen KFO-WeltKieferorthopädie. Nachrichten. 2006;4:1-6.

Melsen, B.; Cacciafesta, V., Dr Birte Melsen on Adult Orthodontic Treatment. Journal of Clinical Orthodontics. 2006;12:703-716.

Melsen, B., Bishara, SE. VIP interview: Birte Melsen. Interview by Samir E. Bishara. World Journal of Orthodontics. 2006;(7)3:313-316.

Pretorius, JA., Melsen, B., Nel JC., Germishuys PJ. A histomorphometric evaluation of factors influencing the healing of bone defects surrounding implants. The International journal of oral & maxillofacial implants. 2005;20(3):387-398.

Melsen, B. When should skeletal anchorage be used within orthodontics? Revue d'orthopédie dento-faciale. 2006;40:41-61.

Pedersen, TK., Kofod, T., Nørholt, SE. Development of the maxilla after vertical ramus distractin in growing patients5th International Congress of Maxillofacial and Craniofacial Distraction, Medimond, International Proceedings 2006. 2006:87-92.

Pedersen, TK., Nørholt, SE., Melsen, B. Distraction Osteogenesis of the Dentoalveolar Anterior Segment in the Mandible 5th International Congress of Maxillofacial and Craniofacial Distraction, Medimond, International Proceedings 2006. 2006:55-59.

Melsen, B. Mini-implants: Where are we? Journal of Clinical Orthodontics. 2005;39(9):539-547.

Bassarelli, T., Dalstra, M. & Melsen, B. Changes in clinical crown height as a result of transverse expansion of the maxilla in adults. Europ J Orthod 2005;27: 121-128.

Cattaneo, P.M., Dalstra, M. & Melsen B. The finite element method: A tool to study orthodontic tooth movement. J Dental Res 2005;84: 428-433.

Verna, C., Dalstra, M., Lee, T.C. & Melsen, B. Microdamage in porcine alveolar bone due to functional and orthodontic loading. Europ J Morphology 2005;42: 3-11.

Valimaki, V.V., Moritz, N., Yrjans, J.J., Dalstra, M. & Aro, H.T. Peripheral quantitative computed tomography in evaluation of bioactive glass incorporation with bone. Biomaterials 2005;26: 6693-6703.

Kofod, T., Cattaneo, P.M., Dalstra, M. & Melsen, B. Three-dimensional finite element analysis of the mandible and temporomandibular joint during vertical ramus elongation by distraction osteogenesis. J Craniofac Surg 2005;16: 586-593.

Cattaneo, P.M., Kofod, T., Dalstra, M. & Melsen, B. Using the finite element method to model the biomechanics of the asymmetric mandible before, during and after skeletal correction by distraction osteogenesis. Comp Meth in Biomech Biomed Eng 2005;8: 157-165.

Sakima, M.T., Dalstra, M. & Melsen, B. How does temperature influence the properties of rectangular nickel-titanium wires? Europ J Orthod 2005;28(3):282-91.

Küseler A, Pedersen TK, Gelineck J, Herlin T. A two-year follow-up study of enhanced magnetic resonance imaging and clinical examination of the temporomandibular joint in children with idiopathic juvenile arthritis. J Rheumatol 2005;32(1):162-9.

Kofod T, Noerholt S E, Pedersen T K, Jensen J. Reliability of distraction vector transfer in unilateral vertical distraction of the mandibular ramus. J Craniofac Surg. 2005 Jan;16(1):15-22.

Kofod T, Noerholt S E, Pedersen T K, Jensen J. Unilateral mandibular ramus elongation by intraoral distraction osteogenesis.J Craniofac Surg. 2005 Mar;16(2):247-54.

Kofod T, Pedersen T K, Noerholt S E, Jensen J. Stereolitographic models for simulation and transfer of vector in vertical distraction of the mandibular ramus. A technical note. J Craniofac Surg. 2005 Jul;16(4):608-14.

Pedersen T K, Melsen B. Bidfunktionslære set i ortodontistens optik. Tandlægebladet 2005;109:286-90.

Verna C, Troiani S, Luzi C, Melsen B. Passive and active overlay systems. J Clin Orthod. 2004 Dec;38(12):673-6; quiz 671-2.

Verna C, Dalstra M, Lee TC, Cattaneo PM, Melsen B. Microcracks in the alveolar bone following orthodontic tooth movement. a morphological and morphometric study. Eur J Orthod. 2004 Oct;26(5):459-67.

Cacciafesta V, Sfondrini MF, Melsen B, Scribante A. A 12 month clinical study of bond failures of recycled versus new stainless steel orthodontic brackets. Eur J Orthod. 2004 Aug;26(4):449-54

Sakima MT, Sakima CG, Melsen B. The Validity of superimposing oblique cephalometric radiographs to assess tooth movement: an implant study. Am J Orthod Dentofacial Orthop. 2004 Sep;126(3):344-53.

Kuseler A, Pedersen TK, Barlach J, Gelineck J, Sangill R, Melsen B, Herlin T. Contrast-enhanced MRI compared to histological findings in the temporomandibular joint of antigen-induced arthritis in young rabbits. Clin Exp Rheumatol. 2004 Jul-Aug;22(4):441-6.

Liu D, Vandahl BB, Birkelund S, Nielsen LB, Melsen B. Secretion of osteopontin from MG-63 cells under a physiological level of mechanical strain in vitro - (35S) incorporation approach. Eur J Orthod. 2004 Apr;26(2):143-9.

Kalia S, Melsen B, Verna C. Tissue reaction to orthodontic tooth movement in acute and chronic corticosteroid treatment. Orthod Craniofac Res 2004 Feb;7(1):26-34.

Dalstra M, Melsen B. Does the transition temperature of Cu-NiTi archwires affect the amount of tooth movement. Craniofac Res. 2004 Feb;7(1):21-5.

Fiorelli G, Melsen B, Modica C. Two-vector mechanics. Prog Orthod. 2003;4(2):62-73. English, Italian.

Verna C, Melsen B. Tissue reaction to orthodontic tooth movement in different bone turnover conditions. Orthod Craniofac Res. 2003 Aug;6(3):155-63.

Verna C, Dalstra M, Melsen B. Bone turnover rate in rats does not influence root resorption induced by orthodontic treatment.
Eur J Orthod. 2003 Aug;25(4):359-63.

Allais D, Melsen B. Does labial movement of lower incisors influence the level of the gingival margin? A case-control study of adult orthodontic patients. Eur J Orthod. 2003 Aug;25(4):343-52.

Rizzo L, Cacciafesta V, Melsen B. Clinical comparison between a modified light-curing denture base resin and a conventional composite resin for orthodontic bonding. Prog Orthod. 2003;4:8-14.

Lazaridou-Terzoudi T, Kiyak HA, Moore R, Athanasiou AE, Melsen B. Long-term assessment of psychologic outcomes of orthognathic surgery. J Oral Maxillofac Surg. 2003 May;61(5):545-52.

Melsen B, Dalstra M. Distal molar movement with Kloehn headgear: is it stable? Am J Orthod Dentofacial Orthop. 2003 Apr;123(4):374-8.

Cattaneo PM, Dalstra M, Melsen B. The transfer of occlusal forces through the maxillary molars: a finite element
study. Am J Orthod Dentofacial Orthop. 2003 Apr;123(4):367-73.

Benedetti, M, Bosch C, Melsen B. Changes Occuring During and After Treatment of Class III Malocclusion with Rapid Palatal Expansion and Face Mask. Wrld J Orthod 2002;3( 3):199-210

Melsen B, Biaggini P. The ray set: a new technique for precise indirect bonding. J Clin Orthod. 2002 Nov;36(11):648-54

Petersen J.N., Haagerup A, Nørholt S.E., Pedersen T.K., Børglum A.D., Mosekilde L. Pyknodysostose - diagnostiske overvejelser og behandling af to patienttilfælde. Tandlægebladet 2002;106:2-8

Oxlund, H., Dalstra, M., Ejersted, C. & Andreassen, T.T. Parathyroid hormone induces formation of new cancellous bone with substantial mechanical strength at a site where it had disappeared in old rats. Europ J Endocrinology 2002;146:431-438

Dalstra, M., Cattaneo, P.M., Beckmann, F. & Hauge, E.M. High-resolution micro-tomography of cortical bone. In: Annual report 2002. Publ.: HASYLAB, Hamburg, Germany

Cattaneo, P.M., Dalstra, M., Beckmann, F., Donath, T. & Melsen, B. High-resolution micro-tomography of orthodontically loaded dental implants. In: Annual report 2002. Publ.: HASYLAB, Hamburg, Germany

Dalstra, M., Cattaneo, P.M., Beckmann, F. & Melsen, B. High-resolution micro-tomography of the human tooth/bone complex. In: Annual report 2002. Publ.: HASYLAB, Hamburg, Germany

Kalia S, Melsen B. Interdisciplinary approaches to adult orthodontic care. Orthod. 2001 Sep;28(3):191-6.

Donker HJ, Melsen B, Frandsen EVG. Bacterial degradation of composite bonding materials. Clin. Orthod. Res 2001 4:112-118

Cacciafesta V, Melsen B. Mesial bodily movement of maxillary and mandibular molars with segmented mechanics: a case report. Clin. Orthod. Res. 2001 Aug;4(3):182-8

Liu D, Melsen B. Reappraisal of Class II molar relationships diagnosed from the lingual side. Clin. Orthod. Res. 4:97-104, 2001

Fiorelli G, Melsen B, Modica C. Differentiated orthodontic mechanics for dental midline correction. J Clin Orthod. 2001 35(4):239-44

Bassarelli T, Melsen B. Expansion: how much can the periodontium tolerate? Clin Orthod Res. 2001 4(4):235-241

Pedersen TK, Jensen JJ, Melsen B, and Herlin T. Resorption of the temporomandibular Condylar bone According to Subtypes of Juvenile Chronic Arthritis. J Rheumatol. 2001 28:2109-15

Cacciafesta V, Sfondrini MF. Correcting a Single-Tooth Anterior Crossbite with Lingual Segmented Mechanics. J Clin orthod. 2001 10(35):612-614

Dalstra M, Cattaneo PM, Beckmann F and Melsen B. High-Resolution CT scanning of Dental Implants using Synchrotron Radiation (II-00-064 EC). Annual report, Hasylab, Hamburg, Tyskland. 12-14, 2001

Dalstra M, Beckmann F, Cattaneo PM, Hauge EM and Melsen F. High-Resolution CT scanning of Cortical Bone using Synchrotron Radiation (II-00-064 EC). Annual report, Hasylab, Hamburg, Tyskland. 10-12, 2001

Dalstra M, Verna C, Cacciafesta V, Andreassen TT, Melsen B. Micro-computed tomography to evaluate bone remodeling and mineralization. In: Advances in Experimental Medicine and Biology. 496:9-19, 2001

Melsen B. Tissue reaction to orthodontic tooth movement – a new paradigm. European Journal of Orthodontics. 23:671-681, 2001

Cattaneo, P.M., Dalstra, M. & Frich, L.H. A three-dimensional finite element model from computed tomography data: a semi-automated method. J Eng Med, Proc Inst Mech Eng Part H. 215:203-213, 2001

Giesen, E.B.W., Ding, M., Dalstra, M. & van Eijden, T.M.G.J. Mechanical properties of cancellous bone in the human mandibular condyleare anisotropic. J Biomechanics. 34:799-803, 2001

Oxlund, H., Dalstra, M. & Andreassen, T.T. Statin given perorally to adult rats increases cancellous bone mass and compressive strength. Calcified Tissue Int. 69:299-304, 2001

Melsen, B., Dalstra, M. & Cattaneo, P.M. Réaction osseuse au déplacement dentaire provoqué - Osseous reaction to orthodontic tooth movement. J Parodontologie  & d'Implantologie Orale. 20:313-329, 2001

Stødkilde-Jørgensen H, Jurik, AG, Dalstra M, Lynnerup N, Gregersen M, Boel LW, Bindslev DA, Pedersen CB, Kruse

A, Hansen ES, Jørgensen CS, Jacobsen NO, Asingh P. Grauballemanden. Ugeskrift for læger. 163(51):7226-7229, 2001

Melsen, B. Lingually inclined incisors.World Journal of  Orthodontics 2000;1:71-78

Fiorelli G, Melsen B, Modica C. The design of custom orthodontic mechanics. Clinical Orthodontics and Research 2000;3:210-219

Melsen B, Costa A.Cargo inmediata de implantes utilizados como anclaje en ortodoncia. Acta Dent Int 2000;1(4):205-210

Melsen B, Costa A.Cargo inmediata de implantes utilizados como anclaje en ortodoncia. Acta Dent Int 2000;1(4):205-210

Costa A, Dalstra M, Melsen B. L’Aarhus Anchorage System Ortognatodonzia Italiana. 2000;4(9):487-496

Cacciafesta V, Paulsen, HU. Direct bonding of cast splint Herbst appliances: a clinical comparison between a resin-reinforced glass ionomer adhesive and a composite resin. Progress in Orthodontics. 2000;2:4-8

Cacciafesta V. Difference in bonding/debonding chair time between a resin-modified, self-cured glass ionomer cement and a composite resin: a randomized clinical trial. Progress in Orthodontics. 2000;2:9-13

Melsen B. Orthodontic "state of the art". Revista Dental Press de Orthodontia e Ortopedia Facial.2000;6(5):1-6

Küseler A, Melsen B. Orthodontic Treatment: Art or Science. Journal of Clinical Orthodontics. 2000;6(34):371-376

Dalstra M, Denes G, Melsen B. Titanium-niobium, a new finishing wire alloy. Clinical Orthodontic and Research.2000;3:6-14

Melsen B, Costa A. Immediate loading of implants used for orthodontic anchorage. Clinical Orthodontic and Research 2000;3:23-28

Verna C, Dalstra M, Melsen B. The rate and the type of orthodontic tooth movement is influenced by bone turnover in a rat model. European Journal of Orthodontics. 2000;22(4):343-62

Christensen FB, Dalstra M, Sejling F, Overgaard S, Bunger C. Titanium-alloy enhances bone-pedicle screw fixation: mechanical and histomorphometrical results of titanium-alloy versus stainless steel. Eur Spine J. 2000;9(2):97-103

Melsen B. Accroissement des possibilités thérapeutiques orthodontiques à l’aide de l’ancrage Aarhus (Widening the orthodontic possibilities with the Aarhus Anchorage). Journal de parodontologie & d’implantologie orale. 2000;19:333-347

Melsen B, Verna C. A rational approach to orthodontic anchorage. Progress in orthodontics. 2000;1:10-22

Cacciafesta V, Melsen B. The rectangular loop: Biomechanical principles and clinical applications in three-dimensional control of single-tooth discrepancies. Progress in orthodontics. 2000;1:23-36

Menghi C, Planert J, Melsen B. 3-D Experimental Identification of Force Systems from Orthodontic Loops in First Order Corrections. Angle Orthod 1999;69(1):49-57

Fiorelli G, Melsen B. The "3-D occlusogram" software. Am J Orthod Dentofac Orthop 1999;116:363-368

Melsen B. Interview. Scientific Journal of the Greek Orthodontic Society. 1999;2:1-8

Melsen B. Biological Reaction of Alveolar Bone to Orthodontic Tooth Movement. Angle Orthod 1999;69:151-158

Miethke RR, Melsen B. Effect of variation in tooth morphology and bracket position on first and third order correction with preadjusted appliances. Am J Orthod Dentofac Orthop 1999;116:329-335

Fiorelli G, Melsen B. The "3-D occlusogram" software. Am J Orthod Dentofac Orthop 1999;116:363-368

Melsen B, Verna C. A rational approach to orthodontic anchorage. Prog Orthod 1999;1:10-22

Cacciafesta V, Melsen B. The rectangular loop: Biomechanical principles and clinical applications in three-dimensional control of single-tooth discrepancies. Prog Orthod 1999;1:23-36

Verna C, Melsen B, Melsen F. Differences in static cortical bone remodeling parameters in human mandible and iliac crest. Bone 1999 Nov;25(5):577-83

Verna C, Zaffe D, Siciliani G. Histomorphometric study of bone reactions during orthodontic tooth movement in rats. Bone 1999 Apr;24(4):371-9

Dalstra M, Melsen B. Force systems developed by six different cantilever configurations. Clin Orthod Res 1999 Feb;2(1):3-9

Pizzoni L, Ravnholt G, Melsen B. Frictional Forces related to Self-Ligating Brackets. Eur J Orthod 1998;20:283-291

Melsen B, Fiorelli G. The Role of Computerized Orthodontics in the Future. IN: The Future of Orthodontics. Carels C, Willems G.(Eds.) Leuven University Press, Belgium. 1998:171-179

Melsen B, Kölsen Pedersen J, Costa A. Zygoma Ligatures - An Alternative Anchorage in the upper Jaw. J Clin Orthod 1998;32:154-158

Costa A, Raffaini M, Melsen B. Miniscrews as Orthodontic Anchorage: A Preliminary Report. Int J Adult Orthod Orthognath Surg 1998;13:201-209

Paulsen HU, Rabol A, Solvsteen Sorensen S. Bone Scintigraphy of Human Temporomandibular Joints during Herbst Treatment. Eur J Orthod 1998;4:369-374

Klit Pedersen T. Clinical Aspects of Orthodontic Treatment for Children with Juvenile Chronic Arthritis. Acta Odontol Scand 1998;56:366-368

Paulsen HU, Andreasen JO. Eruption of Premolars subsequent to autotransplantation. A longitudinal radiographic study. Eur J Orthod 1998;1:45-55

Bosch C, Melsen B, Vargervik K. Importance of the Critical-Size Bone Defect in Testing Bone-Regenerating Materials. J Craniofac Surg 1998;9:310-316

Melsen B. Asymmetrien - eine Herausforderung an die kieferorthopädische Diagnostik and Therapie. Kieferorthop 1998;12:215-232

Cacciafesta V, Bosch C, Melsen B. Clinical Comparison between a Resin-reinforced Self-cured Glass Ionomer and a CompositeResin for Direct Bonding of Orthodontic Brackets. Part I: Wetting with Water. Clin Orthod Res 1998;1:


Küseler A, Klit Pedersen T, Herlin T, Gelineck J. Contrast Enhanced Magnetic Resonance Imaging as a Method to Diagnose Early Inflammatory Changes in the Temporomandibular Joint in Children with Juvenile Chronic Arthritis. J Rheumatol 1998;25:1406-1412

Melsen B, Bosch C. Different approaches to anchorage. Angle Orthod 1997;67 (1):23-30

Laino A, Melsen B. Orthodontic treatment of a patient with multidisciplinary problems. Am J Orthod & Dentofac Orthop 1997;111:141-148

Melsen B, Fontenelle A. Place de L'orthodontie dans les Traitements Interdisciplinaires; L'orthodontie Francaise 1997;1:68:121-138

Paulsen H.U., Karle A, Herskind, A.Analyse des Articulations Temporo-mandibulaires d'un Cas Traité par Appareil de Herbst en fin de Puberté. Revue D'orthopédie Dento Faciale 1997;31:295-306

Grymer L, Bosch C. The Nasal Septum and the Development of the Midface. A Longitudinal Study of a Pair of Monozygotic Twins. Rhinology 1997;35:6-10

Melsen B, Konstantellos V, Lagoudakis M, Planert J. Combined Intrusion and Retraction Generated by Cantilevers with Helical Coils. J Orofac Orthop 1997;58:232-241

Huggare J, Skindhöj B. A New Method for Assessing Masticatory Performance: a feasibility and reproducibility study. J Oral Rehab 1997;24:490-495

Hjorth T, Melsen B, Möller, E. Masticatory Muscle Function after Unilateral Condylar Fractures; a prostective and quantitative electromyographic study.Eur J Oral Science 1997;105:298-304

Melsen B, Klemt B. Adjunctive Orthodontics as Part of Interdisciplinary Treatment. Int J of Adult Orthod & Orthognat Surg 1997;12:233-242

Mavreas D, Melsen B. Changes in the Mechanical Advantage of the Masseter and Temporal Muscles following Surgical Correction of Mandibular Prognathism. Int J Adult Orthod & Orthognat Surg 1997;12:215-225

Milano B, Melsen B. Guided Tissue Regeneration Using Bioresorbable Membranes; What is the limit in the treatment of combined periapical and marginal lesions. Int J Perio & Rest Dent 1997;17:417-425

Paulsen, H.U. Morphological changes of the TMJ condyles of 100 patients treated with the Herbst appliance in the period of puberty to adulthood; a long-term radiographic study. Eur J Orthod 1997;19:657-668

Paulsen, H.U. Premolar autotransplantation: Biological methods, using natures own materials in orthodontic treatment. Essays written in honor of Dr. Gaylord. Sachdeva, R,ed. Dallas, USA. The First International Baylor Orthodontic Symposium. 1997;367-384

Smith R.A; Vargervik K; Kearns G; Bosch C; Koumjian JT. Placement of an Endosseous Implant in a Growing Child with Ectodermal Dysplasia. Oral Surg Oral Med Oral Pathol 1997;75:669-673

Kragskov J, Bosch C, Sindet-Pedersen S, Gyldensted C. Comparison of the Reliability of Craniofacial Anatomic Landmarks Based on Cephalometric Radiographs and Three-dimensional CT scans. Cleft Palate Craniofac J 1997;34:111-116